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ANDRIY YABLUCHANSKIY

Andriy Yabluchanskiy,
MD*, PhD
 

Associate Professor

BIO

Zsofia Szarvas

Zsofia Szarvas,
MD*, PhD

Postdoctoral Research Fellow

BIO

Cheryl Adams

Cheryl Adams,
RN

Clinical Study Coordinator

BIO

Cade Ballard

Cade Ballard,
BS

Graduate Student
 

BIO

Mukli Peter

Peter Mukli,
MD*, PhD
 

Assistant Professor  

BIO

Zalan Kaposzta,
MD*

Postdoctoral Research Scholar

BIO

Peterfi Anna

Zsuzsanna Tucsek-Cardon, PhD

Clinical Study Coordinator

BIO

Norbert Sandor Dosa

Norbert Sandor Dosa,
MD*

Associate Research Scholar

BIO

Camila Bonin Pinto

Camila Bonin Pinto,
BS, MS, PhD
 

Assistant Professor

BIO

Rafal Gulej

Rafal Gulej,
MSc,  PhD

Postdoctoral Research Fellow

BIO

Cameron Owens

Cameron Owens,
MD/PhD

Neurology Resident
 

BIO

Langley Ana Clara

Ana Clara da C. P. Langley,
MSc,  PhD

Assistant Professor

BIO

Mihaly Muranyi

Mihaly Muranyi,
ME

Staff Scientist
 

BIO

Jeng Shi Kong,
BS

PhD Candidate
 

BIO

Gerolab Alumni:

  • Anna Peterfi, MD*
  • Tamas Csipo, MD*
  • Agnes Lipecz, MD*
  • Gabor Fulop, MD*, PhD
  • Sam Detwiller, MD
  • Loren Olay, MD

Our OU collaborators:

OU-Health Sciences Center:

Department of Neurosurgery:

Department of Neurology:

Department of Medicine:

Department of Psychiatry and Behavioral Sciences:

Department of Cell Biology:

OU-Norman:

Our international and nation-wide collaborators:

US collaborators:

  • Joseph A. Baur, PhD, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
  • Farzaneh A. Sorond, MD, Northwestern Univerisity, Chicago, IL
  • Fanny Elahi, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY
  • Michael L Rohan, PhD, Laureate Institute for Brain Research, Tulsa, OK
  • Jonathan D. Wren, PhD, Oklahoma Medical Research Foundation, OKC, OK
  • Norman Hord, PhD, Oklahoma State University, Stillwater, OK
  • Yong Cheng, PhD, Oklahoma State University, Stillwater, OK

Collaborators in Canada:

Collaborators in Europe:

Our science (2026):

Ungvari A, Gulej R, Patai R, Papp Z, Toth A, Szabó AÁ, Podesser BK, Sótonyi P, Benyó Z, Yabluchanskiy A, Tarantini S, Maier AB, Csiszar A, Ungvari Z. Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases. Geroscience. 2025 Jan 3. PMID 39754010

da C Pinaffi-Langley AC, Tarantini S, Hord NG, Yabluchanskiy A. Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies. Antioxidants (Basel). 2024 Dec 18. PMID 39765880

Owens CD, Pinto CB, Szarvas Z, Muranyi M, da C Pinaffi-Langley AC, Peterfi A, Mukli P, Detwiler S, Olay L, Kaposzta Z, Smith K, Kirkpatrick AC, Saleh Velez F, Tarantini S, Csiszar A, Ungvari ZI, Prodan CI, Yabluchanskiy A. COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment. Biomolecules. 2024 Dec 18. PMID 39766328

Ungvari Z, Fekete M, Varga P, Fekete JT, Buda A, Szappanos Á, Lehoczki A, Mózes N, Grosso G, Menyhart O, Munkácsy G, Tarantini S, Yabluchanskiy A, Ungvari A, Győrffy B. Impact of adherence to the Mediterranean diet on stroke risk. Geroscience. 2025 Jan 7. PMID 39777701

Fekete M, Lehoczki A, Szappanos Á, Toth A, Mahdi M, Sótonyi P, Benyó Z, Yabluchanskiy A, Tarantini S, Ungvari Z. Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health. Geroscience. 2025 Jan 7. PMID 39777702

Fekete M, Varga P, Ungvari Z, Fekete JT, Buda A, Szappanos Á, Lehoczki A, Mózes N, Grosso G, Godos J, Menyhart O, Munkácsy G, Tarantini S, Yabluchanskiy A, Ungvari A, Győrffy B. The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis. Geroscience. 2025 Jan 11. PMID 39797935

Peterfi A, Pinaffi-Langley ACDC, Szarvas Z, Muranyi M, Kaposzta Z, Adams C, Pinto CB, Mukli P, Kotliar K, Yabluchanskiy A. Dynamic retinal vessel analysis: flickering a light into the brain. Front Aging Neurosci. 2025 Jan 6. PMID 39834618

Negri S, Reyff Z, Troyano-Rodriguez E, Milan M, Ihuoma J, Tavakol S, Shi H, Patai R, Jiang R, Mohon J, Boma-Iyaye J, Ungvari Z, Csiszar A, Yabluchanskiy A, Moccia F, Tarantini S. Endothelial Colony-Forming Cells (ECFCs) in cerebrovascular aging: Focus on the pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and treatment prospects. Ageing Res Rev. 2025 Jan 28. PMID 39884362

Natarajan D, Ekambaram S, Tarantini S, Nagaraja RY, Yabluchanskiy A, Hedrick AF, Awasthi V, Subramanian M, Csiszar A, Balasubramanian P. Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice. Aging (Albany NY). 2025 Feb 19. PMID 39976587

Patai R, Kiss T, Gulej R, Nyul-Toth A, Csik B, Chandragiri SS, Shanmugarama S, Tarantini S, Ungvari A, Pacher P, Mukli P, Yabluchanskiy A, Csiszar A, Ungvari Z. Patai R, Kiss T, Gulej R, Nyul-Toth A, Csik B, Chandragiri SS, Shanmugarama S, Tarantini S, Ungvari A, Pacher P, Mukli P, Yabluchanskiy A, Csiszar A, Ungvari Z. Geroscience. 2025 Feb 20. PMID 39976844

Csik B, Vali Kordestan K, Gulej R, Patai R, Nyul-Toth A, Shanmugarama S, Mukli P, Ungvari A, Balsara KE, McNall RY, Razzaghi T, Tarantini S, Yabluchanskiy A, Ungvari Z, Csiszar A. Cisplatin and methotrexate induce brain microvascular endothelial and microglial senescence in mouse models of chemotherapy-associated cognitive impairment. Geroscience. 2025 Feb 20. PMID 39976845

Patai R, Csik B, Nyul-Toth A, Gulej R, Vali Kordestan K, Chandragiri SS, Shanmugarama S, Tarantini S, Mukli P, Ungvari A, Yabluchanskiy A, Ungvari Z, Csiszar A. Persisting blood-brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment. Geroscience. 2025 Feb 21. PMID 39982666

Chandragiri SS, Nyul-Toth A, Negri S, Patai R, Gulej R, Csik B, Shanmugarama S, Vali Kordestan K, Nagykaldi M, Mukli P, Ungvari A, Yabluchanskiy A, Ungvari Z, Tarantini S, Csiszar A. Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain. Geroscience. 2025 Mar 25. PMID 40131589

Csik B, Nyúl-Tóth Á, Gulej R, Patai R, Kiss T, Delfavero J, Nagaraja RY, Balasubramanian P, Shanmugarama S, Ungvari A, Chandragiri SS, Kordestan KV, Nagykaldi M, Mukli P, Yabluchanskiy A, Negri S, Tarantini S, Conley S, Oh TG, Ungvari Z, Csiszar A. Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood-Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice. Aging Cell. 2025 Apr 1. PMID 40167015

Patai R, Patel K, Csik B, Gulej R, Nagaraja RY, Nagy D, Chandragiri SS, Shanmugarama S, Kordestan KV, Nagykaldi M, Ekambaram S, Ungvari A, Yabluchanskiy A, Tarantini S, Benyo Z, Csiszar A, Ungvari Z, Nyul-Toth A. Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening. Geroscience. 2025 Apr 2. PMID 40169521

Nyul-Toth A, Shanmugarama S, Patai R, Gulej R, Faakye J, Nagy D, Nagykaldi M, Kiss T, Csipo T, Milan M, Ekambaram S, Negri S, Nagaraja RY, Csiszar A, Brown JL, Van Remmen H, Ungvari A, Yabluchanskiy A, Tarantini S, Ungvari Z. Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia. Geroscience. 2025 Apr 8. PMID 40199795

Kallai A, Ungvari A, Csaban D, Orfi Z, Lehoczki A, Harasztdombi J, Yabluchanskiy A, Benyó Z, Szappanos Á, Tarantini S, Sorond F, Sótonyi P, Andrikovics H, Ungvari Z. Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID). Geroscience. 2025 Apr 11. PMID 40214958

Milan M, Troyano-Rodriguez E, Ihuoma J, Negri S, Rudraboina R, Kosmider A, Awasthi S, Balasubramanian P, Conley S, Yabluchanskiy A, Csiszar A, Ungvari Z, de Cabo R, Tarantini S. Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging. Aging Cell. 2026 Feb 25. PMID 41521387

Toba H, Halade GV, DeLeon-Pennell KY, Chiao YA, Yabluchanskiy A, Holm Nielsen S, Chalise U, Becirovic-Agic M, de Castro Braz LE, Lindsey ML. Cellular and Molecular Signals of Cardiac Wound Healing After Myocardial Infarction. Am J Physiol Heart Circ Physiol. 2026 Jan 14. doi: 10.1152/ajpheart.00891.2025. Online ahead of print. PMID 41533392

Gulej R, Patai R, Chandragiri SS, Nagykaldi M, Brunner E, Mukli P, Nagy D, Kordestan KV, Ekambaram S, Shanmugarama S, Nagaraja RY, Yabluchanskiy A, Tarantini S, Csiszar A, Ungvari Z. Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice. Geroscience. 2026 Feb 20. PMID 41714560

Gulej R, Patai R, Ungvari A, Tordai A, Huffman DM, Tarantini S, Yabluchanskiy A, Ungvari Z, Csiszar A. Plasma-based strategies for systemic rejuvenation: critical perspectives on clinical translation. Geroscience. 2026 Feb 20. PMID 41721191

Ihuoma J, Milan M, Negri S, Troyano-Rodriguez E, Rudraboina R, Kosmider A, Awasthi S, Csiszar A, Ungvari Z, Yabluchanskiy A, Balasubramanian P, Tarantini S. LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia. Redox Biol. 2026 Mar 10. PMID 41831270

Pinaffi-Langley ACDC, Zuraikat FM, St-Onge MP, Yabluchanskiy A. Potential impact of urolithin A on pathways relevant to sleep health: a mini review. Front Nutr. 2026 Mar 4. PMID 41859662

Nagy D, Kordestan KV, Patai R, Gulej R, Chandragiri SS, Nagaraja RY, Shanmugarama S, Ekambaram S, Brunner E, Kristof R, Nagykaldi M, Sirpal P, Yabluchanskiy A, Balsara KE, McNall RY, Ungvari Z, Csiszar A. Long-term cerebrovascular effects of cyclophosphamide and vincristine: endothelial senescence, impaired DNA repair signaling, and blood-brain barrier dysfunction. Geroscience. 2026 Apr 30. PMID 42062707

Jarajapu YPR, Yabluchanskiy A. Special collection on advancing pharmacotherapy for age-related diseases: Bridging treatment gaps and innovations for the aging population. J Pharmacol Exp Ther. 2026 Apr. PMID 42067253

Negri S, Milan M, Rudraboina R, Tavakol SA, Reyff Z, Ihuoma J, Troyano-Rodriguez E, Patai R, Gulej R, Jung W, Abushukair H, Yabluchanskiy A, Ungvari Z, Csiszar A, Balasubramanian P, Rudolph MC, Wellberg EA, Oh TG, Tanter M, Tarantini S. Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood-brain barrier integrity and neurovascular coupling. J Cereb Blood Flow Metab. 2026 May 5. PMID 42083907

Mukli P, Muranyi M, Lipecz Á, Szarvas Z, Csípő T, Fekete M, Fazekas-Pongor V, Peterfi A, Fehér Á, Dosa N, Kaposvári C, Aliquander A, Hung WY, Major D, Kaposzta Z, Matiscsák A, Dörnyei G, Benyo Z, Patai R, Csík B, Gulej R, Ungvari A, Pónyai PT, Győrffy E, Kállai A, Sándor M, Varga P, Tabak AG, Tarantini S, Ádány R, Merkely B, Csiszar A, Yabluchanskiy A, Ungvari Z. Age- and cognitive load-related variability and entropy of gait: integrating coefficient of variation, median absolute deviation, and permutation entropy of spatiotemporal parameters into the Semmelweis Study gait assessment framework. Geroscience. 2026 May 8. PMID 42101743

Negri S, Milan M, Rudraboina R, Ihuoma J, Tavakol SA, Troyano-Rodriguez E, Vali Kordestan K, Csiszar A, Yabluchanskiy A, Youssef I, Chopra R, Tanter M, Tarantini S. Focused ultrasound opens the blood-brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling. J Cereb Blood Flow Metab. 2026 May 13. PMID 42130251

Saleh Velez F, Owens CD, Hotson J, Loggini A, Oliveira Santos AL, Rudyk D, Mercado Pena D, Zuniga-Gutierrez M, Cedeno-Bruzual M, Robayo LB, Gutierrez C, Singleton K, Stuart Z, Sidorov E, Yabluchanskiy A, Pinto CB. NIH Stroke Scale and age predict early post-stroke cognitive impairment. Front Stroke. 2026 Apr 28. PMID 42131684

Ekambaram S, Patai R, Gulej R, Kiss T, Chandragiri SS, Nagy D, Kordestan KV, Lakat T, Tarantini S, Mukli P, Yabluchanskiy A, Ungvari A, Benyó Z, Csiszar A, Ungvari Z. Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle. Geroscience. 2026 May 14. PMID 42133166

Negri S, Milan M, Rudraboina R, Troyano-Rodriguez E, Kosmider A, Awasthi S, Ihuoma J, Yabluchanskiy A, Csiszar A, Rudolph MC, Natarajan D, de Cabo R, Balasubramanian P, Tarantini S. Rethinking dietary fat for the aging brain: the roles or ketosis and fat quality in cerebrovascular aging and VCID. Crit Rev Food Sci Nutr. 2026 May 23. PMID

Saleh Velez F, Cedeno-Bruzual M, Zuniga-Gutierrez M, Mercado Pena D, Ballard CL, Kong JS, Pinaffi-Langley ACDC, Owens CD, TucsekCardon Z, Szarvas Z, Muranyi M, Kaposzta Z, Mukli P, Boada Robayo L, Tarantini S, Ungvari Z, Yabluchanskiy A, Pinto CB. Transcranial magnetic stimulation from healthy brain aging to Alzheimer's disease: a review on mechanisms, therapeutic potential, and future clinical directions. Front Aging Neurosci. 2026 May 8. PMID 42182564

Tarantini S, Milan M, Negri S, Rudraboina R, Troyano-Rodriguez E, Ihuoma J, Kosmider A, Awasthi S, Jung W, Abushukair H, Varshney R, Mullen G, Nagaraja R, Uppari N, Ahmad M, Balasubramanian P, Conley S, Yabluchanskiy A, Csiszar A, Ungvari Z, Cleuren A, Rudolph M, Tanter M, Oh TG, de Cabo R. Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging. Res Sq [Preprint]. 2026 Jun 2. PMID 42282001

Dosa N, Limvaree I, Pinto CB, Saleh Velez F, Kaposzta Z, Szarvas Z, Pope ZC, Csiszar A, Razaq W, Nipp RD, Yabluchanskiy A, Mukli P. Chemotherapy-related cognitive impairment and non-pharmacological interventions targeting the nervous system: a systematic review. Front Psychiatry. 2026 Jun 2. PMID 42311573

Stanford MD, Akbari Fakhrabadi A, Buelow AA, Matney JE, Mixon C, Akubude AJ, Nwafor I, Yabluchanskiy A, Larson RD, Larson DJ, Kellawan JM. Training status augments mechanisms of rapid‑onset vasodilation in healthy young adults. J Appl Physiol (1985). 2026 Jun 26. PMID 42359819

Mohammed S, Jiang C, Pennington T, Bhaskaran S, Ohene-Marfo P, Kneuper KF, Georgescu C, Pitts K, Tran A, Peng Z, Singh A, Yang Z, Li T, Hannafon B, Houchen C, Wren JD, Yabluchanskiy A, Galvan V, Ahsan N, Kinter M, Lewis TL Jr, Deepa SS. A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver. Aging Cell. 2026 Jul. PMID 42399678

*Currently not licensed in the US