https://labs.ouhsc.edu/brainstimulationneurorehab/Research Parent Page: Research id: -1 Active Page: Research id: 36109 Portal ID: 336

Research

The Brain Stimulation and Neurorehabilitation Laboratory is a research laboratory dedicated to the investigation of neuromodulation and neurorehabilitation. Our work is driven by clinically relevant and mechanistically informed questions, integrating experimental neuroscience, neurophysiology, and translational research to advance motor and cognitive recovery following neurological injury.


Our research encompasses three interrelated themes that span clinical application and mechanistic investigation.

Mechanistic Neurophysiology and Neurovascular Coupling

A central focus of the laboratory is to provide a mechanistic foundation for optimizing neuromodulation paradigms and personalizing therapies.

Cognitive Recovery and Brain Health

Our research examines how neuromodulation, in combination with cognitive training, can improve memory, attention, and executive function.

Motor Recovery and Neurorehabilitation

We develop and evaluate neuromodulation-based interventions to enhance motor recovery after neurological injury, with stroke serving as a principal disease model.

Methods & Technologies

Transcranial Direct Current Stimulation (tDCS)

Image of a Transcranial Direct Current Stimulation Device connected to a model of a human head.

Transcranial Direct Current Stimulation (tDCS)

We employ both laboratory-based and home-based tDCS platforms to modulate cortical excitability and plasticity. These systems support controlled experimental protocols as well as remote delivery of stimulation in real-world rehabilitation settings, facilitating translational and pragmatic research designs.

 

Transcranial Alternating Current Stimulation (tACS)

Image of a Transcranial Alternating Current Stimulation Device connected to a model of a human head.

By applying oscillatory electrical currents, tACS allows us to probe and modulate rhythmic neural activity. This approach is used to investigate the role of brain oscillations in motor and cognitive processes and to test whether synchronizing or disrupting specific rhythms can enhance recovery.

 

Transcranial Magnetic Stimulation (TMS)

Image of a Transcranial Magnetic Current Stimulation Device connected to a model of a human head.

TMS is used both as a neurophysiological assessment tool and as a therapeutic intervention. We measure cortical excitability, connectivity, and motor thresholds, and implement repetitive TMS (rTMS) protocols designed to support motor and cognitive rehabilitation.

 

Electroencephalography (EEG)

Image of an Electroencephalography Device connected to a model of a human head.

EEG provides high–temporal-resolution recordings of neural activity. In our laboratory, EEG is used to study brain oscillations, cognitive processing, and recovery-related changes in network function, often in combination with neuromodulation protocols.

 

Robotic Transcranial Doppler (TCD)

Image of a Robotic Transcranial Doppler Device connected to a model of a human head.

Robotic TCD allows continuous, operator-independent assessment of cerebral blood flow velocity. This technology is central to our mechanistic investigations of neurovascular coupling and cerebrovascular regulation in health and neurological disease.

 

Wireless fNIRS

Image of a Wireless fNIRS Device connected to a model of a human head.

We use wireless fNIRS to enable flexible assessment of cortical hemodynamics during motor and cognitive tasks in naturalistic and rehabilitation settings. These portable systems support real-time evaluation of neurovascular responses and facilitate studies of neurovascular coupling beyond traditional laboratory environments.

 

Functional Near-Infrared Spectroscopy (fNIRS)

Image of a Functional Near-Infrared Spectroscopy Device connected to a model of a human head.

fNIRS enables non-invasive monitoring of cortical hemodynamics and neurovascular responses during motor and cognitive tasks. By integrating fNIRS with EEG, we capture complementary vascular and electrophysiological signatures of neuromodulation in real time.

 

Digital Video Analysis (DVA)

Plain background image of a Digital Video Analysis Device.

DVA systems provide objective, quantitative assessment of motor performance and recovery trajectories, complementing clinical rating scales, and enhancing the precision of rehabilitation studies.

 

Home-Based Transcranial Direct Current Stimulation (tDCS)

tDCS

We deploy home-based tDCS platforms to enable the safe, supervised delivery of neuromodulation outside the laboratory environment. These systems are designed to support protocol fidelity, remote monitoring, and participant adherence, allowing stimulation to be integrated with rehabilitation and cognitive training in real-world settings. Home-based tDCS facilitates scalable, patient-centered research and expands access to neuromodulation interventions for individuals who face barriers to in-person care, while preserving rigorous experimental control and clinical oversight.