PUBLICATIONS

Shao R, Neil JM, Chen M, Hannafon B, Nipp R, Montgomery A, Frank-Pearce SG, Moxley K, Richardson DL, Elliott J, Benson L, Gossett AG, Businelle MS. A mobile health app for real-time symptom monitoring in patients with cancer during COVID-19: feasibility, acceptability, and utility. BMC Cancer. 2026 Feb 20;26(1):408. doi: 10.1186/s12885-026-15772-2. PMID: 41715027; PMCID: PMC13032350. https://link.springer.com/article/10.1186/s12885-026-15772-2

Hladik C, Elayapillai SP, Dogra S, Bruns M, Wellberg EA, Filatenkov A, Behbod F, Hannafon BN. Nanoluciferase-CD63 labeling reveals extracellular vesicle kinetics in a mouse intraductal model of ductal carcinoma in situ. Breast Cancer Res. 2026 Jan 30;28(1):52. doi: 10.1186/s13058-026-02221-y. PMID: 41618398; PMCID: PMC12931078. https://link.springer.com/article/10.1186/s13058-026-02221-y

Dogra S, Adhikari L, Benbrook DM, Bohn JA, Burgett A, Chandra V, Dockery L, Singh A, McNally L, Rai R, Isingizwe ZR, Richardson DL, Yang Z, Hannafon BN. Harnessing ovarian cancer ascites for translational science: models, biomarkers, and therapeutics. Mol Cancer. 2025 Oct 14;24(1):257. doi: 10.1186/s12943-025-02438-z. PMID: 41088281; PMCID: PMC12522915. https://link.springer.com/article/10.1186/s12943-025-02438-z

Bhandari K, Kong JS, Tanaka T, Dooley WC, Xu C, Hannafon BN, Ding WQ. Exosome-Associated MTA1 in Circulation Is Elevated During Breast Cancer Progression. FASEB J. 2025 Jul 31;39(14):e70872. doi: 10.1096/fj.202500221R. PMID: 40716099; PMCID: PMC12704216. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500221R

Mohammed S, Jiang C, Pennington T, Bhaskaran S, Ohene-Marfo P, Georgescu C, Pitts K, Tran A, Peng Z, Singh A, Yang Z, Li T, Hannafon B, Houchen C, Wren JD, Galvan V, Ahsan N, Kinter M, Lewis TL, Deepa SS. A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver. bioRxiv [Preprint]. 2025 May 3:2025.05.02.651782. doi: 10.1101/2025.05.02.651782. PMID: 40654837; PMCID: PMC12247894. https://www.biorxiv.org/content/10.1101/2025.05.02.651782v1

Elayapillai SP, Dogra S, Hladik C, Lausen J, Bruns M, Gossett AG, Behbod F, Xu C, Zhang R, Ding WQ, Hannafon BN. Preferential release of microRNAs via extracellular vesicles is associated with ductal carcinoma in situ to invasive breast cancer progression. Cancer Lett. 2025 Aug 10;625:217794. doi: 10.1016/j.canlet.2025.217794. Epub 2025 May 17. PMID: 40389020. https://www.sciencedirect.com/science/article/pii/S0304383525003611?via%3Dihub

Figueroa-Hall LK, Burrows K, Alarbi AM, Hannafon BN, Hladik C, Tan C, Ramesh R, Stewart JL, Risbrough VB, Paulus MP, Teague TK. Comparison of Methods for Isolation and Characterization of Total and Astrocyte-Enriched Extracellular Vesicles From Human Serum and Plasma. J Extracell Biol. 2025 Feb 14;4(2):e70035. doi: 10.1002/jex2.70035. PMID: 39958973; PMCID: PMC11826443.https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jex2.70035

Elayapillai SP, Gandhi A, Dogra S, Saunders D, Smith N, Hladik C, Towner RA, Moxley KM, Hannafon BN. Oklahoma nitrone-007 is an effective anticancer therapeutic agent targeting inflammatory and immune metabolism pathways in endometrial cancer. J Pharmacol Exp Ther. 2025 Jan;392(1):100004. doi: 10.1124/jpet.124.002223. Epub 2024 Nov 22. PMID: 39893009; PMCID: PMC13095626.https://www.sciencedirect.com/science/article/pii/S0022356524000235?via%3Dihub

Elayapillai SP, Dogra S, Lausen J, Parker M, Kennedy A, Benbrook DM, Moxley KM, Hannafon BN. ATR inhibition increases reliance on PARP-mediated DNA repair revealing an improved therapeutic strategy for cervical cancer. Gynecol Oncol. 2024 Dec;191:182-193. doi: 10.1016/j.ygyno.2024.10.009. Epub 2024 Oct 19. PMID: 39427557; PMCID: PMC11975412.https://www.sciencedirect.com/science/article/pii/S0090825824011594?via%3Dihub

Burrows K, Figueroa-Hall LK, Stewart JL, Alarbi AM, Kuplicki R, Hannafon BN, Tan C, Risbrough VB, McKinney BA, Ramesh R, Victor TA, Aupperle R, Savitz J, Teague TK, Khalsa SS, Paulus MP. Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder. Transl Psychiatry. 2024 Apr 27;14(1):199. doi: 10.1038/s41398-024-02907-x. PMID: 38678012; PMCID: PMC11055873. https://www.nature.com/articles/s41398-024-02907-x

Undi RB, Ahsan N, Larabee JL, Darlene-Reuter N, Papin J, Dogra S, Hannafon BN, Bronze MS, Houchen CW, Huycke MM, Ali N. Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network. J Virol. 2023 Nov 30;97(11):e0119423. doi: 10.1128/jvi.01194-23. Epub 2023 Oct 20. PMID: 37861336; PMCID: PMC10688311. https://journals.asm.org/doi/full/10.1128/jvi.01194-23?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Dogra S, Elayapillai SP, Qu D, Pitts K, Filatenkov A, Houchen CW, Berry WL, Moxley K, Hannafon BN. Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer. Cancer Lett. 2023 Dec 1;578:216437. doi: 10.1016/j.canlet.2023.216437. Epub 2023 Oct 12. PMID: 37838282; PMCID: PMC10872611. https://www.sciencedirect.com/science/article/pii/S0304383523003889?via%3Dihub

Han Z, MacCuaig WM, Gurcan MN, Claros-Sorto J, Garwe T, Henson C, Holter-Chakrabarty J, Hannafon B, Chandra V, Wellberg E, McNally LR. Dynamic 2-deoxy-D-glucose-enhanced multispectral optoacoustic tomography for assessing metabolism and vascular hemodynamics of breast cancer. Photoacoustics. 2023 Jul 9;32:100531. doi: 10.1016/j.pacs.2023.100531. PMID: 37485041; PMCID: PMC10362308. https://www.sciencedirect.com/science/article/pii/S2213597923000848?via%3Dihub

Burrows K, Figueroa-Hall L, Stewart J, Alarbi A, Kuplicki R, Hannafon B, Tan C, Risbrough V, McKinney B, Ramesh R, Victor T, Aupperle R, Savitz J, Teague K, Khalsa S, Paulus M. Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder. Res Sq [Preprint]. 2023 Jun 16:rs.3.rs-2813878. doi: 10.21203/rs.3.rs-2813878/v1. PMID: 37398092; PMCID: PMC10312986. https://www.researchsquare.com/article/rs-2813878/v1

Burrows, K., Figueroa-Hall, L. K., Alarbi, A. M., Stewart, J. L., Kuplicki, R., Tan, C., Hannafon, B. N., Ramesh, R., Savitz, J., Khalsa, S., Teague, T. K., Risbrough, V. B., & Paulus, M. P. (2023). Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals. Brain, Behavior, & Immunity - Health, 27, 100582. https://doi.org/https://doi.org/10.1016/j.bbih.2022.100582

Hannafon, B. N. (2021). Involvement of the Tumor Microenvironment in the Pathogenesis of Breast Cancer. Am J Pathol, 191(8), 1328-1329. https://doi.org/10.1016/j.ajpath.2021.05.012

Dogra, S., & Hannafon, B. N. (2021). Breast Cancer Microenvironment Cross Talk through Extracellular Vesicle RNAs. Am J Pathol, 191(8), 1330-1341. https://doi.org/10.1016/j.ajpath.2021.03.014

Xu, Y. F., Xu, X., Bhandari, K., Gin, A., Rao, C. V., Morris, K. T., Hannafon, B. N., & Ding, W. Q. (2021). Isolation of extra-cellular vesicles in the context of pancreatic adenocarcinomas: Addition of one stringent filtration step improves recovery of specific microRNAs. PLoS One, 16(11), e0259563. https://doi.org/10.1371/journal.pone.0259563

Xu, Y. F., Xu, X., Gin, A., Nshimiyimana, J. D., Mooers, B. H. M., Caputi, M., Hannafon, B. N., & Ding, W. Q. (2020). SRSF1 regulates exosome microRNA enrichment in human cancer cells. Cell Commun Signal, 18(1), 130. https://doi.org/10.1186/s12964-020-00615-9

Xu, Y. F., Hannafon, B. N., Khatri, U., Gin, A., & Ding, W. Q. (2019). The origin of exosomal miR-1246 in human cancer cells. RNA Biol, 16(6), 770-784.

Xu, Y. F., Xu, X., Gin, A., Nshimiyimana, J. D., Mooers, B. H. M., Caputi, M., Hannafon, B. N., & Ding, W. Q. (2020). SRSF1 regulates exosome microRNA enrichment in human cancer cells. Cell Commun Signal, 18(1), 130. https://doi.org/10.1186/s12964-020-00615-9

Xu, Y. F., Hannafon, B. N., Khatri, U., Gin, A., & Ding, W. Q. (2019). The origin of exosomal miR-1246 in human cancer cells. RNA Biol, 16(6), 770-784.

Hannafon, B. N., Gin, A. L., Xu, Y. F., Bruns, M., Calloway, C. L., & Ding, W. Q. (2019). Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Cell Commun Signal, 17(1), 13. https://doi.org/10.1186/s12964-019-0325-7

Hannafon, B. N., & Ding, W. Q. (2019). Functional Role of miRNAs in the Progression of Breast Ductal Carcinoma in Situ. Am J Pathol, 189(5), 966-974. https://doi.org/10.1016/j.ajpath.2018.06.025

Hannafon, B. N., Cai, A., Calloway, C. L., Xu, Y. F., Zhang, R., Fung, K. M., & Ding, W. Q. (2019). miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study. BMC Cancer, 19(1), 642. https://doi.org/10.1186/s12885-019-5839-2

Hannafon, B. N., & Ding, W. Q. (2018). miRNAs as Biomarkers for Predicting the Progression of Ductal Carcinoma in Situ. Am J Pathol, 188(3), 542-549. https://doi.org/10.1016/j.ajpath.2017.11.003

Jiao, Y., Watts, T., Xue, J., Hannafon, B., & Ding, W. Q. (2018). Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1. BMC Cancer, 18(1), 1042. https://doi.org/10.1186/s12885-018-4946-9

Xu, Y. F., Hannafon, B. N., Zhao, Y. D., Postier, R. G., & Ding, W. Q. (2017). Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer. Oncotarget, 8(44), 77028-77040. https://doi.org/10.18632/oncotarget.20332

Xu, Y. F., Hannafon, B. N., & Ding, W. Q. (2017). microRNA regulation of human pancreatic cancer stem cells. Stem Cell Investig, 4, 5. https://doi.org/10.21037/sci.2017.01.01

Jiao, Y., Hannafon, B. N., Zhang, R. R., Fung, K. M., & Ding, W. Q. (2017). Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions. Oncotarget, 8(11), 17908-17920. https://doi.org/10.18632/oncotarget.14702

Jiao, Y., Hannafon, B. N., & Ding, W. Q. (2016). Disulfiram's Anticancer Activity: Evidence and Mechanisms. Anticancer Agents Med Chem, 16(11), 1378-1384. https://doi.org/10.2174/1871520615666160504095040

Hannafon, B. N., Trigoso, Y. D., Calloway, C. L., Zhao, Y. D., Lum, D. H., Welm, A. L., Zhao, Z. J., Blick, K. E., Dooley, W. C., & Ding, W. Q. (2016). Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res, 18(1), 90. https://doi.org/10.1186/s13058-016-0753-x

Wang, S., Hannafon, B. N., Lind, S. E., & Ding, W. Q. (2015). Zinc Protoporphyrin Suppresses β-Catenin Protein Expression in Human Cancer Cells: The Potential Involvement of Lysosome-Mediated Degradation. PLoS One, 10(5), e0127413. https://doi.org/10.1371/journal.pone.0127413

Hannafon, B. N., & Ding, W. Q. (2015). Cancer stem cells and exosome signaling. Stem Cell Investig, 2, 11. https://doi.org/10.3978/j.issn.2306-9759.2015.05.02

Hannafon, B. N., Carpenter, K. J., Berry, W. L., Janknecht, R., Dooley, W. C., & Ding, W. Q. (2015). Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer, 14, 133. https://doi.org/10.1186/s12943-015-0400-7

Zhang, S., Xue, J., Zheng, J., Wang, S., Zhou, J., Jiao, Y., Geng, Y., Wu, J., Hannafon, B. N., & Ding, W. Q. (2015). The superoxide dismutase 1 3'UTR maintains high expression of the SOD1 gene in cancer cells: The involvement of the RNA-binding protein AUF-1. Free Radic Biol Med, 85, 33-44. https://doi.org/10.1016/j.freeradbiomed.2015.04.012

Xue, J., Moyer, A., Peng, B., Wu, J., Hannafon, B. N., & Ding, W. Q. (2014). Chloroquine is a zinc ionophore. PLoS One, 9(10), e109180. https://doi.org/10.1371/journal.pone.0109180

Wang, S., Hannafon, B. N., Wolf, R. F., Zhou, J., Avery, J. E., Wu, J., Lind, S. E., & Ding, W. Q. (2014). Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation. J Nutr Biochem, 25(5), 515-525. https://doi.org/10.1016/j.jnutbio.2013.12.011

Xue, J., Wang, S., Wu, J., Hannafon, B. N., & Ding, W. Q. (2013). Zinc at sub-cytotoxic concentrations induces heme oxygenase-1 expression in human cancer cells. Cell Physiol Biochem, 32(1), 100-110. https://doi.org/10.1159/000350128

Wang, S., Avery, J. E., Hannafon, B. N., Lind, S. E., & Ding, W. Q. (2013). Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/β-catenin signaling pathway. Biochem Pharmacol, 85(11), 1611-1618. https://doi.org/10.1016/j.bcp.2013.03.011

Hannafon, B. N., & Ding, W. Q. (2013). Intercellular communication by exosome-derived microRNAs in cancer. Int J Mol Sci, 14(7), 14240-14269. https://doi.org/10.3390/ijms140714240

Wang, S., Hannafon, B. N., Zhou, J., & Ding, W. Q. (2013). Clofibrate induces heme oxygenase 1 expression through a PPARα-independent mechanism in human cancer cells. Cell Physiol Biochem, 32(5), 1255-1264. https://doi.org/10.1159/000354524

Hannafon, B. N., Sebastiani, P., de las Morenas, A., Lu, J., & Rosenberg, C. L. (2011). Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res, 13(2), R24. https://doi.org/10.1186/bcr2839

Liu, T., Hannafon, B., Gill, L., Kelly, W., & Benbrook, D. (2007). Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria. Mol Cancer Ther, 6(6), 1814-1822. https://doi.org/10.1158/1535-7163.Mct-06-0279

Benbrook, D. M., Kamelle, S. A., Guruswamy, S. B., Lightfoot, S. A., Rutledge, T. L., Gould, N. S., Hannafon, B. N., Dunn, S. T., & Berlin, K. D. (2005). Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Invest New Drugs, 23(5), 417-428. https://doi.org/10.1007/s10637-005-2901-5